MRI abnormalities seen in our cohort
| MR abnormalities | All participants | EDI and no additional features | EDI and additional features |
| Specific abnormalities likely to explain EDI or point towards a diagnosis | |||
Hypoxic ischaemic injury:
| 25 | 1 | 24 |
| Toxic metabolic | 17 | 0 | 17 |
| Brain malformation | 37 | 2 | 35 |
| Phakomatoses/tumours | 3 | 1 | 2 |
| Previous infection | 0 | 0 | 0 |
| Hydrocephalus | 3 | 0 | 3 |
| Total | 85 | 4 | 81 |
| Specific or non-specific abnormalities not likely to explain EDI | |||
| Posterior fossa abnormalities, such as Chiari malformation | 6 | 1 | 5 |
| Cavum septum pellucidum | 2 | 0 | 2 |
| Under-opercularisation of the Sylvian fissure | 0 | 0 | 0 |
| Reduced volume of white matter/grey matter | 21 | 2 | 19 |
| Delayed myelination | 12 | 0 | 12 |
| Non-specific white matter abnormality or focal gliosis | 30 | 2 | 28 |
| Arachnoid cyst | 2 | 0 | 2 |
| Optic nerve hypoplasia without evidence of septic optic dysplasia | 0 | 0 | 0 |
| Subdural collection/effusion | 0 | 0 | 0 |
| Non-specific MRS abnormalities | 2 | 1 | 1 |
| Total | 75 | 6 | 69 |
EDI, early developmental impairment.