Table 2

Examples of evidence-informed clinical guideline areas covered during 2005–2015

Disease-specific treatmentsSupportive careTreatment of common emergenciesPrevention
Severe malaria: Quinine loading doses (2005), artesunate as first-line therapy (2010)
Pneumonia: First-line antibiotic treatment (2005); Amoxil for indrawing pneumonia (2010 and 2015)
Meningitis: First-line antibiotic treatment (2005); steroids (2010)
Diarrhoea: Zinc treatment (2010)
Neonatal sepsis: Once daily gentamicin (2005);
sickle cell disease: hydroxyurea prophylaxis in under 5s (2013)
Feeding: Regimens for F75/F100 in severe malnutrition (2005); use of RUTF in malnutrition (2010); time of initiation of feeding in preterm babies (2005 and 2015); use of breast milk fortifiers (2005 and 2015); rate of increasing feeds (2010 and 2015)
Respiratory support: Treatment of neonatal apnoea with caffeine (2010); CPAP in neonatal respiratory distress (2015)
First-line anticonvulsant regimens in children (2005) and newborns (2010);
bolus glucose for possible hypoglycaemia (2005); fluid bolus in severely ill children (2013); newborn resuscitation (2005 and updated in line with new international guidance in 2010)
Alcohol handrubs for infection control (2010); 
chlorhexidine cleaning of the umbilical cord (2013); antibiotic prophylaxis to prevent neonatal sepsis in at-risk babies (2015)
  • CPAP, continuous positive airway pressure, RUTF, ready to use therapeutic foods.