Table 5

WHO severity criteria in patients with and without major interventions in165 children with imported falciparum malaria

Characteristics, n (%)≥1 Major interventions (n=45)0 Major intervention (n=120)OR (95% CI)*p Value*
WHO characteristics
Impaired consciousness (GCS<15)27/45 (60.0%)17/120 (14.2%)9.1 (3.9 to 21.5)<0.0001
Seizure5/45 (11.1%)4/120 (3.4%)3.6 (0.9 to 14.2)0.05
Circulatory collapse14/45 (31.1%)0/120 (0%)111 (6.4 to 1911)†<0.0001
Respiratory distress4/45 (8.9%)2/119 (1.7%)5.7 (1.0 to 32.6)0.27
Coagulation disorders2/45 (4.4%)1/120 (0.8%)5.5 (0.5 to 62.6)0.12
Jaundice12/45 (26.7%)10/120 (8.3%)4.0 (1.6 to 10.1)<0.01
Renal failure10/45 (22.2%)2/120 (1.7%)16.9 (3.5 to 80.6)<0.0001
Haemoglobinuria5/45 (11.1%)4/120 (3.4%)3.6 (0.9 to 14.2)0.05
Hypoglycaemia (<2.2 mmol/L)2/39 (5.1%)0/77 (0%)10 (0.5 to 221)†0.05
Anaemia (<50 g/L)6/45 (13.3%)0/110 (0%)36 (2 to 661)†<0.0001
Parasitaemia (>10%)14/43 (32.6%)9/105 (8.6%)5.1 (2.0 to 13.1)<0.001
Acidosis‡14/41 (34.2%)4/84 (4.8%)10.4 (3.1 to 34.2)<0.0001
Hyperlactataemia (>5 mmol/L)4/23 (17.4%)1/9 (11.1%)1.7 (0.2 to 17.5)0.66
Bilirubin concentration >50 µmol/L11/34 (32.4%)4/71 (5.6%)8.0 (2.3 to 27.6)<0.001
Additional characteristics
Anaemia (<70 g/L)27/45 (60.0%)8/110 (7.3%)19.1 (7.5 to 48.7)<0.0001
Thrombocytopenia (<50 000 platelets/mm322/45 (48.9%)10/111 (9.0%)9.7 (4.0 to 23.2)<0.0001
  • *Fisher's exact test.

  • †An approximate OR was calculated by adding 0.5 to each cell.

  • ‡Acidosis was defined as HCO3 concentration <15 mmol/L and/or base excess >−10 and/or pH <7.35.

  • GCS, Glasgow Coma Scale.