Table 1

Characteristics of included studies

Age (years)
AuthorCountryPeriod of studySource of dataSample sizeMedianMeanRange
All leukaemias combined
 Das et al43India1961–1972Hospital records*69n/an/an/a
 Garcia Calatayud et al25Spain1995–2000Hospital records*29n/an/an/a
 Hasanbegovic26Bosnia1997–2003Hospital records*1306.3n/an/a
 Karimi28Iran1997–2002Hospital records†280n/an/an/a
 La Grutta et al30Italy1960–1978Hospital records*33436.10–15
 Meighan33Canada1948–1960(a) Saskatchewan Cancer Commission records(b) Hospital records (c) Death certificates (d) Pathology reports‡106n/an/an/a
 Meighan32USA1950–1961(a) Hospital records (b) Death certificates‡2583.0n/a0–14
 Rajarajeswari and Viswanathan37India1968–1977Hospital records*100n/an/a0–11
 Thulesius et al41Sweden1984–1995(a) Regional Tumour Registry (b) Hospital records (c) Primary care records25n/a6.6n/a
 Zahid et al42Pakistan1992–1994(a) Hospital records (b) Parent/patient-completed data extraction form*62n/a8.1n/a
All acute leukaemias combined
 Biswas et al18India2003–2005Hospital records*75n/an/a1.8–14
 Hassan et al27India1987–1990Hospital records*45n/an/an/a
 Robazzi et al 39Brazil1995–2004Hospital records*4066.2n/a0.8–15
 Sinigaglia et al40Italy1984–1999Hospital records*1225.66.60.7–17.3
Acute lymphoid leukaemias
(i) Acute lymphocytic leukaemia
 Atay et al16Turkey1993–2000Hospital records*34n/a5.82–14
 Bernbeck et al17Germany1995–2004Hospital records*1895.8n/a0.1–17.8
 Drozynsky et al44Poland1996–2001Hospital records*3057.53–17
 Ma et al31Hong Kong1985–1994Hospital records*734.3n/a0.4–14.2
Acute myeloid leukaemias
(i) Acute myeloid leukaemia
 Choi and Simone23USA1962–1973Hospital records*1718n/a0–22
 Klinowska et al29Poland1955–1969Hospital records*106n/an/an/a
 Revesz et al38Hungary1971–1982Leukemia Working Party Hospital records§123n/an/an/a
(ii) Acute promyelocytic leukaemia
 Chan et al20USA1974–1980Hospital records¶168.5n/a2–17
 Da Costa Moraes et al24Brazil2002–2006Hospital records*1510n/a4–17
(iii) Acute megakaryocytic leukaemia
 Paredes-Aguiler et al36Mexico1990–2002Hospital records*296.5n/a0.3–16
Chronic myeloid leukaemias
(i) Chronic myeloid leukaemia
 Castro-Malaspina et al19France1963–1976Hospital records*39n/an/a2–16
 Chang et al21Taiwan1976–2001Hospital records*47n/an/a2.7–17
 Liu et al45China1994–2009Hospital records*126.4n/a1.2–11
 Millot et al34France1991–2003(a) Clinical trial data (b) Hospital records**4012.5n/a1–18
(ii) Juvenile myelomonocytic leukaemia
 Arico et al14Italy1983–1992National Registry for JCML§221.3n/a0–4
 Arya et al16India1980–1991Hospital records*10n/a1.70.3–4.5
 Castro-Malaspina et al19France1954–1977Hospital records*38n/an/a0.3–5.5
 Chang et al22Taiwan1978–2001Hospital records*16n/a2.50.7–4.0
 Owen et al35UK1971–1986(a) Childhood Cancer Research Group records(b) Hospital records§332.2n/a0.3–8.8
  • *One hospital. †Three hospitals. ‡Regionwide. §Nationwide. ¶Two hospitals. **Sixteen hospitals. N/A, not applicable.