TableĀ 1

Laboratory tests used to evaluate haemostasis in paediatric liver disease, in clinical practice or as research tools

Loss of reserve
Procoagulant systemINR, APTT, fibrinogen
Natural anticoagulantsProtein C, protein S, antithrombin
Fibrinolytic systemD-dimer
Blood cellsPlatelet count
Global coagulation assaysThrombelastography, thromboelastometry,
thrombin generation test, sonorheometry
Vascular flow and endothelial function
Vascular flowDoppler ultrasound, MRI
Portal pressureHepatic venous gradient measurement Surrogate markers
  • Ultrasound (spleen size?)

  • Platelet count (thrombocytopenia?)

  • Endoscopy (varices?)

Endothelial functionvon Willebrand factor
  • APTT, activated partial thromboplastin time; INR, international normalised ratio.