Table 2

Commonly used mesalazine preparations

DrugFormulationOptimal drug release pHSite of drug release
AsacolEnteric coated with Eudragit SpH-dependent delayed release (>7)Terminal ileum and colon
IpocolEnteric coated with Eudragit S>7Terminal ileum and colon
OctasaEnteric coated with Eudragit SpH-dependent delayed release (>7)Terminal ileum and colon
PentasaEthyl cellulose coated microgranulesDiffusion through semipermeable membrane (enteral pH)Duodenum to colon
SalofalkTablets: enteric coated with Eudragit L;
Granules: Eudragit L plus matrix granule structure
pH-dependent delayed release (>6)
Granules have extra delayed release
Terminal ileum and colon
  • Licensed use: Asacol (all preparations) and Salofalk enema are not licensed for use in children under 18 years; Salofalk suppositories, Pentasa tablets and suppositories are not licensed for use in children under 15 years; Pentasa granules and Salofalk granules not licensed for use in children under 6 years.