Commonly used mesalazine preparations
Drug | Formulation | Optimal drug release pH | Site of drug release |
Asacol | Enteric coated with Eudragit S | pH-dependent delayed release (>7) | Terminal ileum and colon |
Ipocol | Enteric coated with Eudragit S | >7 | Terminal ileum and colon |
Octasa | Enteric coated with Eudragit S | pH-dependent delayed release (>7) | Terminal ileum and colon |
Pentasa | Ethyl cellulose coated microgranules | Diffusion through semipermeable membrane (enteral pH) | Duodenum to colon |
Salofalk | Tablets: enteric coated with Eudragit L; Granules: Eudragit L plus matrix granule structure | pH-dependent delayed release (>6) Granules have extra delayed release | Terminal ileum and colon |
Licensed use: Asacol (all preparations) and Salofalk enema are not licensed for use in children under 18 years; Salofalk suppositories, Pentasa tablets and suppositories are not licensed for use in children under 15 years; Pentasa granules and Salofalk granules not licensed for use in children under 6 years.