Differences between rural children with SCA and urban children with and without SCA
| Urban Tanzanian Non-SCA Controls (n=19 [20]) Median (IQR) | Urban Tanzanian SCA (n=54 [65]) Median (IQR) | Rural Kenyan SCA (n=95 [113]) Median (IQR) | P* for comparison between groups | P† for comparison with Tanzanian patients with SCA and controls | P† for comparison between Tanzanian and Kenyan patients with SCA | |
|---|---|---|---|---|---|---|
| Age (years) | 8.0 (4.0–10.4) | 7.3 (5.1–10.6) | 6.4 (3.7–10.1) | 0.216 | ||
| [8.7 (5.5–10.8)] | [7.1 (5.1–10.6)] | [6.5 (1.3–16.5)] | ||||
| BMI z-scores | −0.11 (−0.97 to 0.66) | −0.98 (−1.89 to 0.052) | −1.3 (−2.1 to −0.6) | 0.005 | 0.4 | 0.059 |
| [−0.31 (−1.48 to 0.08)] | [−0.93 (−1.68 to 0.88)] | [−1.33 (−2.04 to 0.58] | ||||
| Haemoglobin (g/dL) | NA | 7.1 (6.6–7.8) [7.1 (6.6–7.8] | 7.5 (6.8–8.2) [7.4 (6.8–8.2)] | 0.076 | ||
| Median daytime haemoglobin Oxygen saturation (%) | 100 (98–100) [100 (98–100)] | 97 (94.8–99.1) [97 (94–100)] | 99 (98.0–100) [99 (98.0–100)] | 0.001 [0.0005] | 0.018 [0.001] | 0.002 [0.0005] |
| Median overnight haemoglobin Oxygen saturation (%) | 98.6 (97.5–99.1) | 97.7 (95.1–99.3) | 99.0 (96.7–99.8) | 0.01 | 0.3 | 0.048 |
| Median minimum haemoglobin Oxygen saturation (%) | 90 (83.5–93) | 87 (78.5–91) | 92 (86–95) | 0.001 | 0.2 | 0.003 |
| Median overnight heart rate (bpm) | 88.0 (81.9–97.5) | 93.3 (85.2–102.9) | 90.2 (79.1–102.1) | 0.3 |
Values in square brackets for whole cohort recruited.
*Kruskal–Wallis test.
†Post hoc comparison using Scheffe's test.
BMI, body mass index; SCA, sickle cell anaemia.