CBF (ml/min) | F | H-I | 5 min | 15 min | 30 min | 60 min | 180 min |
---|---|---|---|---|---|---|---|
Control | 115 ± 32 | 92 ± 18 | 148 ± 43 | 122 ± 46 | 95 ± 47 | 73 ± 23 | 95 ± 17 |
Sham | 174 ± 42* | 176 ± 87 | 155 ± 66 | 125 ± 60 | 117 ± 39* | 100 ± 29 | |
WIN 102 μg/kg | 204 ± 57* | 204 ± 40‡ | 172 ± 50 | 174 ± 12*†‡ | 192 ± 37*†‡ | 114 ± 21 | |
WIN 10−2 μg/kg | 174 ± 41* | 110 ± 40 | 106 ± 41 | 110 ± 24 | 102 ± 26 | 81 ± 28 |
*Versus control; †versus sham; ‡versus WIN55212-2 (WIN) 0.01 μg/kg groups.
CBF, carotid blood flow; F, fetal point; H-I, end of hypoxic–ischaemic injury.