Table 3

Adverse drug reactions (ADR) in paediatric patients

Age groupDrugADRMechanism
NeonatesSulphonamideKernicterusHighly protein bound drug displaces bilirubin
NeonatesChloramphenicolGrey baby syndromeImpaired metabolism
Neonates and young infantsCeftriaxone—calcium solutionsCalcium precipitation in lungsUnknown
Infants and young childrenSodium valproateHepatotoxicityAbnormal metabolism?
ChildrenPropofolPropofol infusion syndromeUnknown, but thought to be dose related
ChildrenVigabatrinVisual field defectsUnknown
AdolescentsMetoclopramideDystoniaUnknown