Table 2

Midazolam clearance in non-critically ill children

Age groupNumber of patientsRange of weight (kg)Mean clearance (mL/kg/min)SDCoefficient of variation (%)Range of clearance (mL/kg/min)Variation ratio in clearanceType of patientsCommentsStudy
>28 days–23 months52.8–12.811.3653NANAMinor surgeryTwo stage PK studyReed et al28
2–11 years611–1713.34419.5–17.82Minor surgeryIndividual data availableRey et al29
1214–38.515.33.12011–232Minor surgeryJones et al30
622–303.21.1541.1–6.56Minor surgeryIndividual data availableKraus et al31
2123.2*NANANA1.3–13.710.5Elective surgerySalonen et al32
1419.5*103.838NANAMinor surgeryTwo stage PK studyReed et al28
88.4–26.29.11.213NANAMinor surgeryPayne et al33
12–18 years20NA10550NANAEndoscopyTolia et al34
262*9.33.840NANAMinor surgeryTwo stage PK studyReed et al28
  • *Mean.

  • NA, not available.