ICS increase n = 9393FDC n=1119+LABA n=2934+LTRA n=1120P value
Age, years (median[IQR])8 (6–10)10 (8–11)9 (6–11)8 (6–10)<0.001
Year of step up (median[IQR])2001 (1998–2006)2006 (2004–2008)2003 (1999–2005)2007 (2004–2008)<0.001
Controlled (%)41.437.739.636.0<0.001
Exacerbation (%)10.415.210.512.7<0.001
ICS >400 microg BUD (%)18.631.032.525.0<0.001
Daily SABA >200 microg (%)39.645.443.543.7<0.001