Route | Tmax | Cmax* | AUC0-t* | t1/2 | CL | Vss |
hr | mg/L | hr*mg/L | hr | L/kr | L | |
IV therapeutic | 0.93 (1.84) | 0.16 (0.06) | 0.54 (0.26) | 3.78 (3.09) | 2.72 (3.10 | 7.16 |
IV microdose | 0.47 (0.72) | 0.30 (0.19) | 0.84 (0.57) | 1.69 (0.88) | 1.76 (1.07) | 2.55 |
Oral therapeutic | 1.05 (0.74) | 0.14 (0.12) | 0.70 (0.79) | 2.62 (3.05) | 2.93 (2.08) | 8.36 |
Oral microdose | 0.65 (0.36) | 0.24 (0.1) | 0.90 (0.43) | 1.64 (1.02) | 1.46 (1.00) | 2.65 |
Data are mean and s.d. * Cmax and AUC0-t are dose normalised.