Demographic and clinical characteristics of children with post-ART TB (TB IRIS and incident TB), TB prior to ART and children who had no TB during the observation period
| TB IRIS (n = 23) | Incident TB (n=32) | p Value* | Never TB (n=286) | TB prior to ARV (n=161) | |
|---|---|---|---|---|---|
| Median age (months) at ART initiation, (IQR) | 6.0 (3.5–8.7) | 6.1 (4.6–11.6) | 0.40 | 5.7 (3.4–9.9) | 11.2 (7.4–15.8) |
| Male (%) | 11 (47.8) | 14 (43.8) | 0.77 | 133 (46.5) | 78 (48.5) |
| Median WAZ at ART initiation (IQR) | −2.73 (−4.32 to −1.69) (n=21) | −1.89 (−3.23 to −0.39) (n=28) | 0.10 | −2.32 (−3.81 to −0.91) (n=265) | −2.8 (−3.84 to −1.1) (n=141) |
| Severe immune suppression (%) | 15 (71.4) (n=21) | 22 (73.3) (n=30) | 0.88 | 155 (63.0) (n=246) | 110 (77.5) (n=142) |
| Median CD4 cell count (IQR) | 930 (485–1723) (n=22) | 942 (553–1384) (n=31) | 0.93 | 759 (351–1491) (n=252) | 681 (431–1226) (n=142) |
| Median CD4% (IQR) | 21.0 (9.0–26.0) (n=21) | 16.9 (13.4–22.5) (n=30) | 0.70 | 19.5 (12.0–28.9) (n=246) | 15.0 (10.5–20.6) (n=142) |
| Median log10 (VL) (IQR) | 6.04 (5.68–6.48) (n=19) | 5.94 (4.97–6.46) (n=26) | 0.29 | 5.82 (5.28–6.41) (n=221) | 5.87 (4.98–6.45) (n=119) |
ART, antiretroviral therapy; TB, tuberculosis; TB IRIS, immune reconstitution or unmasking TB; VL, HIV viral load; WAZ: weight-for-age Z score. *p Value reports comparison between TB IRIS and incident TB groups.