Table 1

Dosing table for individualised maintenance dose for children based on the developed evidence-based dosing regimen and the dosing based on the current regimen

Body weight, (kg)Model-based dosing algorithmTraditional dosing algorithm
PNA <10 days 2.5 ug/kg1.5 per hourPNA > 10 days 5 ug/kg 1.5 per hour10 μg* body weight
per h
(μg/)(μg/h)(μg/h)
0.50.885
12.55.010
1.54.69.215
27.114.120
2.59.919.825
313.026.030
3.516.432.735
420.040.040
4.523.947.745
528.055.950
5.532.264.555
636.773.560
6.582.965
792.670
7.5102.775
8113.180
8.5123.985
913590
9.5146.495
10158.1100
11182.4110
12207.8120
13234.4130
14261.9140
15290.5150
  • PNA, postnatal age.

  • Reproduced from Knibbe, CAJ et al. Morphine glucuronidation in preterm neonates, infants and children younger than 3 years. Clinical pharmacokinetics 2009;48:371–85, with permission from Adis (© Springer International Publishing AG 2012. All rights reserved.)