Table 1

Modified Newcastle Ottawa Score

  • 1. Representativeness of the cohort of preterm born children

Truly representative of preterm infantsTertiary neonatal intensive care unit population; born <32/40; wt <1500 g**
Somewhat representative of preterm infantsSingle centre; infants <37/40; wt <1800 g*
Selected group of patientsSpeciality clinic
Not representative
  • 2. Selection of comparison group (term controls)

Drawn from the same origin as the preterm infantsHospital or community peer (eg, school) selection*
Drawn from a different community
Not reported or no comparison group
  • 3. Ascertainment of prematurity

Hospital recordNotes, dating scan**
Public recordParents hand-held notes, birth certificates, gestation estimate after birth*
Not recorded
  • 1. Comparability on the basis of design or analysis

The study controls for current body habitusMass, body fat (% or index), BMI, height*
The study assesses or allows for pubertal stageTanner stages used*
The study controls for or allows for other concurrent endocrine pathology (eg, growth hormone deficiency) or influence*
Assessment of Insulin Sensitivity****
  • 1. Measurement of Insulin sensitivity

Experimental assessment of Insulin sensitivity, assessor blinded to prematurity or notFor example, glucose disposal during euglycaemic clamp, fasting insulin and glucose with use of HOMA**
Experimental assessment of IS but no report of blinding*
Not reported
  • 2. Adequacy of cohort follow-up

Complete follow-up, that is, all original cohort members tested at current study**
Subjects lost to follow-up ≤20% (ie, unlikely to introduce bias) OR if description of those lost suggest that they were not different from those followed*
Follow-up rate ≤80% and no description of those lost OR description provided indicates substantial difference
Not reported
  • HOMA, homeostasis model assessment.