Table 2

Baseline characteristics of 116 neonates in the original population pharmacokinetic study

TotalHospital 1Hospital 2Hospital 3
NumberMean (SD)Median (range)MeanRangeMeanRangeMeanRange
Patients116
Gender (F/M)57/59
Samples207
Serum vancomycin concentration (mg/l)20.6 (8.3)18.8 (5.1–61.5)20.38.9–44.021.611.0–61.516.85.1–50.0
Birth weight (g)1331 (839)1010 (510–3930)1161510–36401009515–26951704610–3930
Current weight (g)1700 (964)1416 (460–5680)1443460–56801641525–29071990620–4500
PNA (days)26 (25)17 (1–120)233–100352–120231–96
PMA (weeks)33.8 (5.3)32.7 (24.4–49.4)32.426.1–43.933.524.4–42.135.326.4–49.4
Serum creatinine (µmol/l)*48 (33)42 (5–228)465–120518–2284811–180
Ventilation92
PDA†26
IUGR32
Sepsis24
Drug co-administration
 Inotrope24
 Aminoglycoside104
 Ibuprofen27
  • *Enzymatic method.

  • †13 neonates without echocardiography results.

  • F, female; IUGR, intrauterine growth restriction; M, male; PDA, patent ductus arteriosus; PMA, postmenstrual age; PNA, postnatal age.