Table 1

Characteristics of four different oral formulations

TabletPowderSuspensionSyrup
PictureEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image
AppearanceRound biconvex white tabletsFreely flowing powderHomogeneous and opaque liquid after shakingClear solution
Dosing recommendation1 tablet of 4 mm (43.0 mg)250 mg powder (1 sachet)2.5 mL2.5 mL
TasteAimed at neutralAimed at neutralAimed at neutralAimed at neutral
Dosing deviceNot applicableNot applicable (spoon is an example to show the powder and is not dispensed to the participant)3 mL oral syringe with 0.1 mL graduation. The syringe can be attached to the cap of the container3 mL oral syringe with 0.1 mL graduation. The syringe can be attached to the cap of the container
CompositionLactose monohydrate 34.69 g
Maydis amylum 6.46 g
Maydis amylum pregelificatum 1.42 g
Magnesium stearate 0.43 g
Lactose monohydrate 203.7 mg
Maydis amylum 38.0 mg
Maydis amylum pregelificatum 8.3 mg
Total 250 mg
Methylparahydroxybenzoate 46.0 mg aluminiummagnesiumsilicate 484.4 mg
Carboxymethylcellulose 484.5 mg
Citric acid 36.3 mg
Sucrose 12.74 g
Purified water 37.95 g
Microcrystalline cellulosis 2.50 g
Purified water ad 50 mL
Methylparahydroxybenzoate 63.1 mg
Propylparahydroxybenzoate 10.0 mg
Citric acid monohydrate 37.5 mg
Saccharose 8.28 g
purified water ad 50 mL