Comparison of cost-effectiveness thresholds among common childhood cancers: examples from several different countries
| Factor | Brazil | Malawi | El Salvador | El Salvador | China | Brazil | USA | Brazil | Morocco |
|---|---|---|---|---|---|---|---|---|---|
| Type of paediatric cancer | ALL | BL | SR-ALL | HR-ALL | ALL | ALL | ALL | BL | Wilms |
| Source | Howard25 | Hesseling26 | Bonilla37 | Bonilla37 | Tang38 | Brandalise39 | Pui2 | Sandlund40 | Madani41 |
| Event free survival definition | 5 years | 1 year | 5 years | 5 years | 5 years | 5 years | 5 years | 5 years | 5 years |
| Percentage abandoning treatment* | 1% | – | – | – | 48.3% | – | – | – | – |
| Percentage event free survival† | 63% | 48% | 56.3% | 48.6% | 38.5% | 83.6% | 85.6% | 39% | 56.0% |
| Country gross domestic product per capita‡ | $11 900 | $900 | $7600 | $7600 | $8500 | $11 900 | $49 000 | $11 900 | $5100 |
| Country life expectancy‡ | 72.79 | 52.31 | 73.69 | 73.69 | 74.84 | 72.79 | 78.49 | 72.79 | 76.11 |
| Age at diagnosis | 5.4 | 6.9 | 4.6 | 7.1 | 4.7 | 5.3 | 5.3 | 5.5 | 3 |
| Upper limit of very cost effective, US$/case | $257 075 | $14 243 | $147 756 | $129 037 | $58 620 | $344 385 | $1 454 695 | $167 146 | $100 285 |
| Upper limit of cost effective, US$/case | $771 225 | $42 729 | $443 268 | $387 112 | $175 859 | $1 033 156 | $4 364 086 | $501 438 | $300 855 |
*When no abandonment percentage is listed, authors included the statistic as part of overall event free survival calculations.
†In all studies cited, relapse and abandonment were included as events when calculating event free survival.
‡All life expectancy and gross domestic product per capita data obtained from The World Factbook.21
ALL, acute lymphoblastic leukaemia; BL, Burkitt lymphoma.