Univariate and multivariate regression analysis of factors associated with CSF pleocytosis in enteroviral meningitis
| Univariate model | Multivariate model | ||||
|---|---|---|---|---|---|
| Pleocytosis group (n=319) | Non-pleocytosis group (n=71) | p Value† | aOR | 95% CI | |
| Age (month) | 70.04±47.07 | 20.83±34.89 | <0.001* | 0.981§ | 0.973 to 0.989 |
| LOS (day) | 2.93±1.86 | 3.33±1.85 | 0.110 | ||
| Peripheral WBC count (/mm3) | 12337±3881 | 8280±3125 | <0.001* | 0.843¶ | 0.791 to 0.899 |
| Peripheral ANC (/mm3) | 9240±4365 | 4986±3204 | <0.001* | 0.932¶ | 0.886 to 0.980 |
| CRP (mg/dl) | 1.50±1.90 | 0.99±1.13 | 0.386 | ||
| Onset-puncture interval | |||||
| <24 h (n) | 144 | 44 | 0.015*‡ | 0.527** | 0.315 to 0.882 |
| ≥24 h (n) | 175 | 27 | |||
| EV PCR method | |||||
| Nested RT (n) | 236 | 41 | 0.010*‡ | 2.053 | 0.965 to 4.368 |
| GeneXpert (n) | 83 | 30 | |||
Values for age, LOS, peripheral WBC count, ANC, and CRP were shown by mean value±SD.
*p<0.05
†By Mann-Whitney U test.
‡By Pearson χ2 test.
§Reflects the increase in the odds of lack of pleocytosis for each 4-week increase in age.
¶Reflects the increase in the odds of lack of pleocytosis for each 500-cell increase in WBC/Neutrophil count.
**Reflects the increase in the odds of lack of pleocytosis for each 24-h increase in time.
ANC, absolute neutrophil count; aOR, adjusted OR; CI, confidence interval; CRP, C-reactive protein; EV, enterovirus; LOS, length of stay in hospital; PCR, polymerase chain reaction; RT, reverse transcription; WBC, white blood cell.