| Criteria | Case One | Case Two |
|---|---|---|
| Onset alveolar hypoventilation >1.5 years | Yes | Yes |
| Rapid onset obesity | Yes | Yes |
| Hyperprolactinaemia | Yes | Yes |
| Central hypothyroidism | No | No |
| Disordered water balance | Yes | No |
| Failed GH stimulation test | Yes | Yes |
| Corticotrophin deficiency | No | No |
| Delayed/precocious puberty | Not applicable | Not applicable |
| Other | Obstructive sleep apnoea, hyprenatraemia, flat affect, respiratory arrest, altered perception of pain | Obstructive sleep apnoea, flat affect, respiratory arrest |