OR from univariable logistic regression models and PAF of mortality during the first 10 days of life by VSD classification and selected individual signs (n=6924)
| Prevalence, % (95% CI) | OR (95% CI) | PAF,% (95% CI)* | |
|---|---|---|---|
| VSD algorithm | |||
| Mirzapur revised 11-sign | 5.6 (5.1 to 6.2) | 25.9 (15.8 to 42.2) | 55.5 (41.7 to 66.0) |
| Modification F of the Mirzapur revised 11-sign | 7.4 (6.7 to 8.0) | 18.8 (11.5 to 30.6) | 54.6 (40.5 to 65.4) |
| YIS7 | 7.4 (6.8 to 8.1) | 17.4 (10.7 to 28.3) | 53.0 (38.8 to 63.9) |
| Modification Z of the YIS7 | 7.4 (6.8 to 8.1) | 18.6 (11.4 to 30.2) | 54.6 (40.4 to 65.4) |
| SEARCH, 2 out of 7 signs | 0.3 (0.2 to 0.5) | 10.2 (2.3 to 44.5) | 2.6 (−1.3 to 6.3) |
| SEARCH, 1 out of 7 signs | 2.3 (1.9 to 2.6) | 8.7 (4.5 to 16.9) | 14.0 (5.0 to 22.2) |
| Individual signs and symptoms | |||
| Convulsion† | 0.14 (0.07 to 0.27) | 25.5 (5.3 to 122.6) | 2.8 (−0.9 to 6.3) |
| Respiratory rate ≥70/min† | 1.36 (1.10 to 1.66) | 4.6 (1.6 to 13.0) | 4.5 (−1.1 to 9.8) |
| Severe chest in-drawing present†‡§ | 0.17 (0.09 to 0.30) | – | |
| Severe fever (axillary temperature >101°F)† | 0.29 (0.18 to 0.45) | 18.3 (5.2 to 63.9) | 4.1 (−0.5 to 8.4) |
| Moderate to severe fever (axillary temperature ≥100°F)‡ | 1.14 (0.90 to 1.42) | 5.6 (2.0 to 15.7) | 4.7 (−0.9 to 10.0) |
| Moderate to severe hypothermia (axillary temperature <97.5°F)‡ | 3.61 (3.18 to 4.08) | 28.0 (17.2 to 45.8) | 45.9 (32.7 to 56.5) |
| Severe hypothermia (axillary temperature <95.5°F)† | 1.26 (1.01 to 1.55) | 37.9 (21.2 to 67.7) | 26.6 (16.2 to 35.8) |
| Week, abnormal or absent cry† | 0.77 (0.57 to 1.00) | 16.7 (7.3 to 38.5) | 9.5 (2.5 to 15.9) |
| Unconscious†§ | 0.03 (0.00 to 0.10) | – | |
| Lethargic or less than normal movement†‡ | 1.29 (1.03 to 1.58) | 20.7 (10.9 to 39.4) | 17.8 (8.5 to 26.1) |
| Not able to feed or not suck at all, observed† | 1.85 (1.54 to 2.19) | 27.6 (16.0 to 47.7) | 29.1 (17.9 to 38.8) |
| History of feeding problem‡ | 0.53 (0.38 to 0.74) | 5.8 (1.4 to 24.7) | 2.4 (−1.6 to 6.2) |
| Severe skin infection†§ | 0.95 (0.74 to 1.21) | – | |
| Umbilical redness extending to skin†§ | 0.17 (0.09 to 0.30) | – | |
| Jaundice‡ | 2.11 (1.78 to 2.48) | 2.1 (0.7 to 6.9) | 2.3 (−2.7 to 7.0) |
Screening was conducted among all neonates who were assessed at least once during the period, in the intervention arm of the PROJAHNMO-II study. Lists of signs and symptoms for algorithms are presented in online supplementary table 1.
↵* PAF estimated for signs with significant OR only.
↵† Signs included in the 11-sign revised algorithm.
↵‡ Signs and symptoms included in modification F of the 11-sign revised algorithm.
↵§ Absence of the sign predicted mortality perfectly and OR was not estimated.
PAF, population attributable fraction; VSD, very severe disease; YIS7, Young Infant Study 7-sign.