Major | Minor | |
---|---|---|
Dermatological and mucosal | Generalised angioedema (2) Local angioedema (1) Rash and pruritus (1) Generalised erythema (2) Generalised hives (5) | Local hives (1)* Hives at injection site (1) Generalised pruritus without skin rash (0) Generalised prickle sensation (0) Red and itchy eyes (0) |
Cardiovascular | Shock (1)† Hypotension (2)‡ | A reduced peripheral circulation as indicated by the combination of at least 2 of: tachycardia (2); prolonged capillary refill (1); decreased consciousness (2) |
Respiratory | Upper airway angioedema (1) Wheeze (1) Respiratory distress (1) Stridor (0) | Sneezing (1) Sensation of throat closure (1) Dyspnoea (3) Cough (1) Hoarse voice (0) |
Gastroenterological | Not applicable | Nausea (1) Vomiting (1) Diarrhoea (0) Abdominal pain (0) |
Laboratory | Not applicable | Raised serum tryptase (1)§ |
↵* Localised hives were present in one case, but were not contributory to the BCCD.
↵† A clinical diagnosis of uncompensated shock was indicated by the combination of at least three of the following: tachycardia; capillary refill time >3 s; reduced central pulse volume; decreased level of consciousness or loss of consciousness.
↵‡ Respiratory distress was defined by the presence of two or more of the following: tachypnoea; increased use of accessory respiratory muscles (sternocleidomastoid, intercostal, etc); recession; cyanosis; grunting.
↵§ A test for Mast Cell Tryptase (MCT)was only performed in one case, where it was raised 5 h after the reaction.