Table 2

Candidate genes associated with ADHD selecting the most consistently replicated findings

GenePolymorphismORPConsistency
DRD47-repeat allele of VNTR in exon III1.27<0.00001Replicated in four meta-analyses/pooled analyses
DRD5148-bp microsatellite repeat1.220.000095Replicated in four meta-analyses/pooled analyses
DAT1480-bp VNTR in 3′ UTR1.10.002Replicated in two meta-analyses/pooled analyses, did not replicate in four
SNAP25T1065G1.150.03Replicated in two meta-analyses but not same polymorphism
COMT and antisocial behaviour in ADHDVal158Met polymorphism2.82<0.01Replicated in three large independent samples
  • Reported OR and p value are from Gizer et al meta-analysis19 apart from COMT, for which OR and p value are taken from Langley et al.26

  • ADHD, attention deficit hyperactivity disorder; COMT, catechol-O-methyltransferase; DAT1, dopamine transporter gene; DRD4, dopamine D4 receptor gene; DRD5, dopamine D5 receptor gene; SNAP25, synaptosomal-associated protein of 25 kD; UTR, untranslated region; VNTR, variable number tandem repeat.