Pharmacokinetic analysis by cytochrome P450 (CYP)2C19 genotype in infants in group 2
| Wild type (*1/*1) | EMs (*1/*2, *1/*3) | PMs (*2/*2, *2/*3) | p Value | |
|---|---|---|---|---|
| Number | 6 | 3 | 4 | |
| PB concentration, μg/ml† | 22.3 (15.3–26.7) | 16.4 (12.7–29.7) | 14.0 (9.1–22.2) | 0.271 |
| Vd, litres/kg† | 0.60 (0.44–0.90) | 0.60 (0.60–0.92) | 5.30 (5.13–15.71) | 0.695 |
| CL, ml/kg/h† | 9.3 (7.4–11.7) | 5.3 (5.1–15.7) | 14.3 (10.2–18.3) | 0.811 |
↵† Median (range).
CL, clearance; EM, extensive metaboliser; PB, phenobarbital; PM, poor metaboliser; Vd, volume of distribution.