Sensitivity, specificity, likelihood ratio positive, PPV and NPV of identifying mortality during the first 10 days of life by VSD algorithm (n=6924)
| VSD algorithm | Prevalence, % (95% CI) | Sensitivity, % (95% CI) | Specificity, % (95% CI) | Likelihood ratio positive (95% CI) | PPV, % (95% CI) | NPV, % (95% CI) |
|---|---|---|---|---|---|---|
| Mirzapur revised 11-sign | 5.6 (5.1 to 6.2) | 58.0 (45.5 to 69.8) | 94.9 (94.4 to 95.4) | 11.5 (9.1 to 14.3) | 10.3 (7.5 to 13.8) | 99.6 (99.4 to 99.7) |
| Modification F of the Mirzapur revised 11-sign | 7.4 (6.7 to 8.0) | 58.0 (45.5 to 69.8) | 93.2 (92.5 to 93.7) | 8.5 (6.8 to 10.5) | 7.9 (5.7 to 10.5) | 99.5 (99.4 to 99.7) |
| YIS7 | 7.4 (6.8 to 8.1) | 56.5 (44.0 to 68.4) | 93.1 (92.4 to 93.6) | 8.1 (6.5 to 10.2) | 7.6 (5.4 to 10.2) | 99.5 (99.3 to 99.7) |
| Modification Z of the YIS7 | 7.4 (6.8 to 8.1) | 58.0 (45.5 to 69.8) | 93.1 (92.5 to 93.7) | 8.4 (6.7 to 10.4) | 7.8 (5.6 to 10.4) | 99.5 (99.4 to 99.7) |
| SEARCH, 2 out of 7 signs | 0.3 (0.2 to 0.5) | 2.9 (0.4 to 10.1) | 99.7 (99.5 to 99.8) | 9.9 (2.4 to 41.7) | 9.1 (1.1 to 29.2) | 99.0 (98.8 to 99.2) |
| SEARCH, 1 out of 7 signs | 2.3 (1.9 to 2.6) | 15.9 (8.2 to 26.7) | 97.9 (97.5 to 98.2) | 7.5 (4.3 to 13.2) | 7.0 (3.6 to 12.2) | 99.1 (98.9 to 99.3) |
Screening was conducted among all neonates who were assessed at least once during the period, in the intervention arm of the PROJAHNMO-II study. Lists of signs and symptoms for algorithms are presented in online supplementary table 1.
NPV, negative predictive value; PPV, positive predictive value; SEARCH, Society for Education, Action and Research in Community Health; VSD, very severe disease; YIS7, Young Infant Study 7-sign.