Table 2

Summary of reported adverse events (AEs) from 68 studies

AEsFrequency
Musculoskeletal232*
Abnormal liver function tests139
Nausea75
Blood cell count derangements57
Vomiting56
Rash51
Injection site reaction47
Headache41
Hearing/eye associated AEs42
Abdominal pain/discomfort38
Diarrhoea36
Psychiatric disorders18
Dizziness/decreased consciousness13
Pruritus2
Irritability/anxiety/nervousness12
Photosensitivity10
Acute renal failure/impaired renal function9
Abdominal distension8
Allergy/anaphylactoid reaction7
Oral cavity abnormalities6
Bleeding6
Hemiparesis/hypotonia/hyperreflexia/ataxia5
Fever/hot flushes5
Rigors/shivering/tremors4
Interstitial nephritis4
Others34
Not specified98
Total1065
  • * 232 patients had 258 musculoskeletal events.

  • Others include AEs which occurred once, twice or thrice only. These include seizures, haemolytic uraemic syndrome, pseudomembranous colitis, gastro-oesophageal reflux disease, urinary retention, greenish discolouration of teeth, malaise, weight loss, dysuria, heart failure, sinoatrial nodal arrest and tachycardia.

  • Not specified AEs reported as unknown.