Clinical characteristics and indications in neonates included in the pooled intravenous paracetamol study
| Single propacetamol | Repeated propacetamol | Repeated paracetamol | Repeated paracetamol | |
|---|---|---|---|---|
| Allegaert et al13 | Allegaert et al15 | Palmer et al11 | New dataset, PARANEO | |
| Samples (n) | 213 | 107 | 189 | 445 |
| Patients (n) | 30 | 18 | 50 | 60 |
| Route of sampling | Arterial | Arterial | Arterial/venous/capillary | Arterial |
| Postnatal age (range, days) | 1 | 1–76 | 1–144 | 1–28 |
| Postmenstrual age (range, weeks) | 27–40 | 29–43 | 31.7–45 | 27–42 |
| Preterm (<37 weeks) | 20 | 4 | 11 | 23 |
| Extreme preterm (<32 weeks) | 10 | 2 | 1 | 8 |
| Weight (range) | 0.505–4 kg | 0.81–4 kg | 1.2–4.54 kg | 0.6–4.3 kg |
| Low birth weight (<1500 g) | 10 | 3 | 1 | 9 |
| Extreme low birth weight (<1000 g) | 6 | 2 | 1 | 4 |
| Growth restricted (<10th percentile) | 10 | 3 | 11 | 7 |
| Unconjugated bilirubinaemia (μmol/l) | 15.4–80.4 | 1.7–212 | 58–195 | 8.5–256 |
| Main indication for intravenous paracetamol | ||||
| Postoperative analgesia | 1/30 | 16/18 | 48/50 | 33/60 |
| Cardiac surgery | 0 | 3 | 1 | 15 |
| Thoracic surgery | 0 | 6 | 15 | 11 |
| Abdominal surgery | 1 | 3 | 30 | 6 |
| Other | 0 | 4 | 2 | 1 |
| Medical conditions | 29/30 | 2/18 | 2/50 | 27/60 |
| Fever | 0 | 0 | 0 | 3 |
| Traumatic pain | 2 | 0 | 0 | 5 |
| Alprostadil administration | 1 | 2 | 0 | 8 |
| Procedural/respiratory | 26 | 0 | 0 | 8 |
| Other | 0 | 0 | 2 | 3 |
PARANEO, paracetamol in neonates.