Table 1

Study characteristics

StudyInterventionsTemperatureAgeFollow-up time
Lal et al9*G1: paracetamol 10 mg/kg 8 hourly, n=33>38.5°C axillaMean (95% CI) 2.85 years (1.75 to 3.95) and 3.02 (2.34 to 3.7)5 days
G3: paracetamol 10 mg/kg and ibuprofen 10 mg/kg
8 hourly, n=18
Erlewyn-Lajeunesse et al14G1: paracetamol 15 mg/kg single dose, n=37≥38°C tympanic6 months–10 years2 h
G2: ibuprofen 5 mg/kg single dose, n=35
G3: paracetamol 15 mg/kg and ibuprofen 5 mg/kg
single dose, n=36
Nabulsi et al13G2: ibuprofen 10 mg/kg, followed by placebo at 4 h, n=33≥38.8°C rectal6 months–14 years8 h
G3: ibuprofen 10 mg/kg, followed by paracetamol
15 mg/kg at 4 h, n=36
Sarrell et al11G1: paracetamol 12.5 mg/kg 6 hourly, n=154≥38.4°C rectal6 months–3 years10 days
G2: ibuprofen 5 mg/kg 8 hourly, n=155
G3: paracetamol 12.5 mg/kg alternately with ibuprofen
5 mg/kg 4 hourly, n=155
Hay et al10G1: paracetamol 15 mg/kg 4–6 hourly, n=5237.8–41°C axilla6 months–6 years5 days
G2: ibuprofen 10 mg/kg 6–8
hourly, n=52
G3: paracetamol 15 mg/kg 4–6 hourly
and ibuprofen 10 mg/kg
6–8 hourly, n=52
Kramer et al12G1: paracetamol 15 mg/kg followed by placebo at 3 h
and paracetamol 15 mg/kg at 4 h, n=19
>38°C oral (rectal <2 years)6 months–6 years24 h
G3: paracetamol 15 mg/kg followed by ibuprofen
10 mg/kg at 3 h and
placebo at 4 h, n=19
Paul et al15G1: ibuprofen 10 mg/kg followed by
paracetamol 15 mg/kg at 3 h, n=20
>38°C temporal artery6 months–6 years6 h
G2: ibuprofen 10 mg/kg
G3: ibuprofen 10 mg/kg and paracetamol 15 mg/kg
  • * This study also included a nimesulide arm not analysed here.

  • Half of each group were initially loaded with paracetamol and ibuprofen; because there was no difference these were analysed together.