Summary of base-case results and deterministic sensitivity analysis results
| Strategy | Screening strategy | Expected total cost per screening strategy (£) | Difference in costs | Effectiveness CHD detected | Incremental CHD detected | ICER per timely diagnosis of significant CHD (£) | |
|---|---|---|---|---|---|---|---|
| Base-case results | |||||||
| A | Clinical examination alone | 614100 | – | 91.5 | – | – | |
| B | Pulse oximetry as an adjunct to clinical examination (strategy B vs A) | 1358800 | 744700 | 121.4 | 29.9 | 24900 | |
| First threshold analysis: changing the threshold to <95% in either limb or a differential of >3% | |||||||
| A | Clinical examination alone | 613700 | – | 91.5 | – | – | |
| B | Pulse oximetry as an adjunct to clinical examination (strategy B vs A) | 1311100 | 697300 | 121.4 | 29.9 | 23300 | |
| Second threshold analysis: using a threshold of <95% for foot saturations alone | |||||||
| A | Clinical examination alone | 611000 | – | 88.8 | – | – | |
| B | Pulse oximetry as an adjunct to clinical examination (strategy B vs A) | 1278200 | 667200 | 113.7 | 24.9 | 26700 | |
| First cost analysis: doubling the cost for the echocardiogram assessment (£231.14) | |||||||
| A | Clinical examination alone | 685200 | – | 91.5 | – | – | |
| B | Pulse oximetry as an adjunct to clinical examination (strategy B vs A) | 1508200 | 823000 | 121.4 | 29.9 | 27500 | |
| Second cost analysis: using a cost of £4.68 for the pulse oximetry (assuming median duration for carrying out the test as opposed to mean duration) | |||||||
| A | Clinical examination alone | 614100 | – | 91.5 | – | – | |
| B | Pulse oximetry as an adjunct to clinical exam (strategy B vs A) | 1197300 | 583200 | 121.4 | 29.9 | 19500 | |
CHD, congenital heart defect; ICER, incremental cost-effectiveness ratio.