Comparison of thyroid-autoimmunity-positive and -negative patients with CD at the end of follow-up
| TA-positive patients with CD (n=65 (12%)) | TA-negative patients with CD (n=480 (88%)) | |
|---|---|---|
| M/F | 15/50 | 146/334 |
| Mean age at CD diagnosis (years, (mean±SD)) | 4.9±0.6 | 4.9±0.2 |
| Duration of GFD at study entry (years, (mean±SD)) | 7.9±0.9 | 10.2±0.3* |
| Patients with duration of GFD <6 years, % (N) | 89 (47/53) | 92 (48/52) |
| Positive family history for AD, % (N) | 28 (18/65) | 26 (125/480) |
| Positive family history for CD, % (N) | 14 (9/65) | 21 (101/480) |
| Positive DQ2† | 100 (14/14) | 93 (126/136) |
| Positive DQ8† | 0 | 8 (11/136) |
| Weight gain (kg/year)‡ | 1.8±1.0 | 2.1±1.2 |
| Height gain (cm/year)‡ | 3.7±1.5 | 4.0±1.1 |
All values are expressed as mean±SD, if not otherwise specified.
↵* p<0.001.
↵† Human leucocyte antigen was assessed in 14 patients with CD with TA and in 136 patients with CD without TA.
↵‡ These data were evaluated only in prepubertal patients.
AD, autoimmune diseases; CD, coeliac disease; GFD, gluten-free diet; TA, thyroid autoimmunity.