Change in lipids, blood pressure and HsCRP with change in BMI SDS
| Change in BMI SDS over 12 months | |||||||
|---|---|---|---|---|---|---|---|
| (i) Increased (n=20) | (ii) Decreased >0 to <0.25 (n=29) | (iii) Decreased ≥0.25 to <0.5 (n=20) | (iv) Decreased ≥0.5 (n=19) | Group comparison | Group comparison after baseline adjustment | Test of linear trend after baseline adjustment | |
| HDL-C (mmol/l) | |||||||
| Initial mean (SD) | 1.32 (0.19) | 1.21 (0.26) | 1.18 (0.14) | 1.16 (0.27) | p=0.1 | − | − |
| Final mean (SD) | 1.35 (0.20) | 1.27 (0.30) | 1.26 (0.21) | 1.25 (0.31) | p=0.7 | p=0.8 | p=0.4 |
| Mean change (95% CI) | 0.03 (−0.05 to 0.11) | 0.06 (−0.01 to 0.12) | 0.08 (0.02 to 0.14) | 0.09 (−0.01 to 0.18) | − | − | − |
| LDL-C (mmol/l) | |||||||
| Initial mean (SD) | 2.61 (0.51) | 2.70 (0.71) | 2.44 (0.59) | 2.25 (0.64) | p=0.09 | − | − |
| Final mean (SD) | 2.58 (0.49) | 2.66 (0.83) | 2.14 (0.56) | 1.92 (0.66) | p<0.001 | p=0.007 | p=0.002 |
| Mean change (95% CI) | −0.03 (−0.14 to 0.08) | −0.04 (−0.20 to 0.12) | −0.30 (−0.55 to −0.04) | −0.33 (−0.53 to −0.13) | − | − | − |
| TC/HDL-C ratio | |||||||
| Initial geometric mean (range) | 3.40 (2.5–4.8) | 3.75 (2.5–6.1) | 3.54 (2.5–5.3) | 3.42 (1.6–5.0) | p=0.3 | − | − |
| Final geometric mean (range) | 3.35 (2.3–4.6) | 3.56 (1.9–6.0) | 3.10 (2.4–4.1) | 2.84 (1.3–4.0) | p=0.008 | p<0.001 | p<0.001 |
| Geometric mean ratio (95% CI) | 0.99 (0.94 to 1.04) | 0.95 (0.91 to 0.98) | 0.87 (0.82 to 0.93) | 0.82 (0.79 to 0.87) | − | − | − |
| Triglyceride (mmol/l) | |||||||
| Initial geometric mean (range) | 1.04 (0.6–2.7) | 1.20 (0.5–2.3) | 1.12 (0.6–3.0) | 1.04 (0.3–2.0) | p=0.6* | − | − |
| Final geometric mean (range) | 1.14 (0.6–2.6) | 1.13 (0.4–2.2) | 0.97 (0.5–2.0) | 0.73 (0.3–1.3) | p=0.002* | p<0.001* | p<0.001* |
| Geometric mean ratio (95% CI) | 1.09 (0.88 to 1.35) | 0.94 (0.84 to 1.05) | 0.87 (0.76 to 0.99) | 0.70 (0.59 to 0.84) | − | − | − |
| Systolic BP (mm Hg) | |||||||
| Initial mean (SD) | 113.9 (6.3) | 112.7 (10.4) | 112.7 (6.7) | 109.0 (9.4) | p=0.3 | − | − |
| Final mean (SD) | 113.7 (7.8) | 112.1 (7.8) | 108.3 (8.2) | 105.5 (12.0) | p=0.02 | p=0.05 | p=0.01 |
| Mean change (95% CI) | −0.2 (−3.0 to 2.6) | −0.7(−3.3 to 2.0) | −4.4 (−8.0 to −0.8) | −3.5 (−7.6 to 0.7) | − | − | − |
| Diastolic BP (mm Hg) | |||||||
| Initial mean (SD) | 64.9 (7.2) | 67.1 (8.5) | 66.9 (6.3) | 63.9 (4.6) | p=0.4 | − | − |
| Final mean (SD) | 67.8 (9.3) | 67.1 (7.7) | 62.2 (7.8) | 60.8 (7.6) | p=0.01 | p=0.007 | p=0.001 |
| Mean change (95% CI) | 2.9 (−1.1 to 6.9) | 0.0 (−3.3 to 3.3) | −4.7 (−7.8 to −1.6) | −3.1 (−6.9 to 0.8) | − | − | − |
| HsCRP (mg/l) | |||||||
| Initial geometric mean (range) | 2.25 (0.2–7.8) | 2.95 (0.3–34.0) | 2.30 (0.5–9.1) | 1.89 (0.2–10.4) | p=0.5 | − | − |
| Final geometric mean (range) | 2.48 (0.2–7.6) | 3.53 (0.3–15.1) | 2.04 (0.2–19.7) | 1.03 (0.3–14.9) | p=0.02 | p=0.04 | p=0.008 |
| Geometric mean ratio (95% CI) | 1.10 (0.95 to 1.28) | 0.86 (0.55 to 1.33) | 0.89 (0.56 to 1.41) | 0.55 (0.30 to 1.00) | − | − | − |
BMI SDS, body mass index SD score; BP, blood pressure; HDL-C, high-density lipoprotein-cholesterol; HsCRP, high sensitivity C-reactive protein; LDL-C, low-density lipoprotein-cholesterol; TC, total cholesterol.
↵* Adjusting for gender.