Table 5

Adverse event rates where reported classified by AED

Reported % of patients experiencing an adverse event*
Adverse event (no. of RCTs)Carbamazepine (3)Valproate (1)Clobazam (1)Gabapentin (1)Lamotrigine (5)Levetiracetam (2)Oxcarbazepine (3)Stiripentol (2)Topiramate (3)Vigabatrin (5)
CNS
 Headache16–221654–183215–37
 Somnolence9–19321783–24235–35715–135–40
 Cognitive impairment555–20
 Dizziness14–17131–217295–148
 Tremor41112140–3
 Ataxia33–101414
 Diplopia15–717
 ↑ Seizures108
Psychological
 Emotional lability84–131214125–16
 Behaviour disturbance/mood alteration3441024
Gastrointestinal
 Nausea/vomiting811387–221522–36105–11
 Abdominal pain11–13910
General
 Fatigue/asthenia172133–1191315–26
 Increased appetite41150–3
 Decreased appetite45410–1373312–16
 Weight gain4–14213243–519–26
 Weight loss297–17
 Rash85–22
 Alopecia41123
 Drooling610
 Blood disorders1414
 Miscellaneous (one drug only)10 (nystagmus; abnormal gait)10 (hypotonia; dysarthria)3–13 (paraesthesia)6–8 (visual field constriction) 9 (insomnia)
  • * Range indicates adverse event reported in >1 trial.

  • AED, antiepileptic drug; CNS, central nervous system; RCTs, randomised controlled trials.