Differences in neuro-developmental outcomes between extremely preterm children with true negative and false positive SCQ screens using a total SCQ cut-off score of ≥14
| SCQ screen n (%) | ||||
|---|---|---|---|---|
| Outcome | True negative (n=140) | False positive (n=22) | OR (95% CI) | p Value |
| Functional impairment | ||||
| Neuromotor impairment, n (%) | 7 (5.0%) | 4 (18.2%) | 4.22 (1.12 to 15.86) | 0.045 |
| Visual impairment, n (%) | 6 (4.3%) | 4 (18.2%) | 4.96 (1.28 to 19.29) | 0.031 |
| Hearing impairment, n (%) | 1 (0.7%) | 1 (4.5%) | 6.62 (0.40 to 109.89) | 0.254 |
| Cognitive impairment, n (%) | 41 (29.3%) | 15 (68.2%) | 5.17 (2.00 to 113.62) | 0.001 |
| MPC (IQ) scores, mean (SD) | 89.14 (14.26) | 69.68 (19.36) | −19.46 (−28.32 to −10.59)* | 0.000 |
| Overall functional disability, n (%) | 48 (34.3%) | 15 (68.2%) | 4.11 (1.57 to 10.76) | 0.004 |
| Parent SDQ: clinical range† | ||||
| Total difficulties, n (%) | 35 (25.0%) | 16 (72.7%) | 8.00 (2.90 to 22.04) | 0.000 |
| Emotional symptoms, n (%) | 21 (15.0%) | 11 (50.0%) | 5.67 (2.18 to 14.74) | 0.001 |
| Conduct problems, n (%) | 12 (8.6%) | 6 (27.3%) | 4.0 (1.32 to 12.13) | 0.020 |
| Hyperactivity/inattention, n (%) | 28 (20.0%) | 16 (72.75) | 10.67 (3.83 to 29.75) | 0.000 |
| Peer problems, n (%) | 30 (21.4%) | 13 (59.1%) | 5.30 (2.07 to 13.57) | 0.001 |
↵* Mean difference (95% CI).
↵† Behavioural outcomes were assessed using the Strengths and Difficulties Questionnaire (SDQ) completed by parents (n=162). Children with scores >90th percentile of a comparison group of 153 classmates were classified as at risk for clinically significant difficulties in each domain and overall for total difficulties.
MPC, Mental Processing Composite scores from the Kaufman Assessment Battery for Children; SCQ, Social Communication Questionnaire; SDQ, Strengths and Difficulties Questionnaire.