Table 2 Estimation of hypothetical major congenital malformation rate for females treated by monotherapy
CarbamazepineLamotrigineSodium valproateTotal study antiepileptic drugs
Reported MCM rate per 100 pregnancies*2.203.206.20N/A
1993Number of females with epilepsy treated with respective monotherapy50.000.5049.50100.00
per 100 adolescents
Estimated rate of MCMs per 100 pregnancies in adolescents1.100.023.074.19
2006Number of females with epilepsy treated with respective monotherapy30.4034.4035.20100.00
per 100 adolescents
Estimated rate of MCMs per 100 pregnancies in adolescents0.671.102.183.95
  • MCM, major congenital malformation.

  • *Morrow et al3 – figures for females with epilepsy taking that AED during pregnancy.

  • The figures for 1993 and 2006 are for female adolescents aged 12–18, treated with any of the three study drugs in monotherapy.