The cumulative dose of Pred and/or Dex in the UKALL97, UKALL97/01 and the UKALL 2003 protocol.
| Gender | Girls A, B | Boys A, B | Girls C | Boys C |
|---|---|---|---|---|
| UKALL97, 97/01 | ||||
| Duration (week) | 112 | 164 | 118 | 169 |
| Total Pred (mg/m2) | 7728 | 10328 | 6728 | 9328 |
| Total Dex | 1230 | 1652 | 1067 | 1490 |
| Pred-Equivalent (mg/m2) | 8204 | 11019 | 7117 | 9938 |
| Pred | 69 | 62 | 57 | 55 |
| Pred-Equivalent (mg/m2/week) | 73 | 67 | 60 | 58 |
| UKALL2003 | ||||
| Duration (week) | 112 | 164 | 118 | 170 |
| Dex (D1) (mg/m2) | 1080 | 1470 | 1010 | 1430 |
| Pred-Equivalent | 7203 | 9805 | 6736 | 9538 |
| Dex (D2) (mg/m2) | 1160 | 1550 | 0 | |
| Pred-Equivalent | 7737 | 10338 | ||
| Pred-Equivalent (D1) | 64 | 60 | 57 | 56 |
| Pred-Equivalent (D2) mg/m2/week | 69 | 63 | ||
Each protocol was classified into A, B, C regimens. Dex doses were converted to Pred equivalents by multiplying the Dex dose by a conversion factor of 6.67 which is based on the relative anti-inflammatory properties of the two drugs. In the UKALL97/01, children were randomised to receive either Pred or Dex, whereas in the UKALL2003, children were randomised to treatment intensification; delayed intensification I (D1) and delayed intensification II (D2).
Dex, Dexamethasone, Pred, Prednisolone.