Distribution of polymorphisms in relation to change of BMI and SDS-BMI among 240 overweight children completing the one-year lifestyle intervention
| FTO | N (%) | Total | ||
| Mean change of BMI in kg/m2 (95% CI) | ||||
| Mean change of SDS-BMI (95% CI) | ||||
| INSIG2 | ||||
| GG carrier | CG carrier | CC carrier | ||
| TT carrier | 29 (12) | 28 (12) | 5 (2) | 62 (26) |
| −1.49 (−2.35 to −0.63) | −0.68 (−1.56 to 0.19) | −0.79 (−2.87 to 1.28) | −1.07 (−1.69 to−0.44) | |
| −0.33 (−0.45 to −0.21) | −0.29 (−0.41 to−0.17) | −0.29 (−0.57 to −0.01) | −0.31 (−0.39 to−0.22) | |
| AT carrier | 62 (26) | 47 (20) | 7 (3) | 116 (48) |
| −0.91 (−1.50 to−0.32) | −1.06 (−1.74 to −0.38) | 1.71 (−0.05 to 3.46) | −0.81 (−1.27 to −0.35) | |
| −0.29 (−0.37 to −0.21) | −0.31 (−0.41 to −0.22) | 0.06 (−0.18 to 0.30) | −0.28 (−0.34 to −0.21) | |
| AA carrier | 34 (14) | 23 (10) | 5 (2) | 62 (26) |
| −0.86 (−1.66 to −0.06) | −0.25 (−1.21 to 0.72) | 4.74 (2.67 to 6.82) | −0.18 (−0.80 to 0.44) | |
| −0.36 (−0.47 to −0.26) | −0.24 (−0.37 to −0.11) | 0.51 (0.22 to 0.79) | −0.25 (−0.33 to −0.16) | |
| Total | 125 (52) | 98 (41) | 17 (7) | 240 (100) |
| −1.03 (−1.45 to −0.61) | −0.76 (−1.24 to −0.28) | 1.87 (0.71 to 3.02) | −0.71 (−1.11 to −0.47) | |
| −0.32 (−0.12 to 0.06) | −0.29 (−0.36 to −0.23) | 0.09 (−0.07 to 0.25) | −0.28 (−0.32 to −0.23) | |
| Unadjusted linear change per additional INSIG2 allele | ||||
| Change of BMI +0.89 kg/m2 (p<0.001) | ||||
| Change of SDS-BMI +0.12 (p<0.001) | ||||
| Unadjusted linear change per additional FTO allele | ||||
| Change of BMI +0.44 kg/m2 (p = 0.05) | ||||
| Change of SDS-BMI +0.03 (p = 0.3) | ||||
BMI, body mass index.