Table 1 Comparison between indications reported in summary product characteristics (SPC) and those in the British National Formulary (BNF) of oral paracetamol and pre-dosed spray salbutamol
DrugSPC*BNF
Paracetamol, oral suspension (250 mg/5 ml)<1 year: 2.5 ml (60 mg) every 4–6 h1–3 months: 30–60 mg every 8 h
1–4 years: 2.5–5 ml (60–120 mg) every 4–6 h3–12 months: 60–120 mg every 6–8 h
>4 years: 5–10 ml (120–240 mg) every 4–6 h1–5 years: 120–150 mg every 4–6 h
6–12 years: 250–500 mg every 4–6 h
12–18 years: 500 mg every 4–6 h
For severe symptoms:
1–3 months: 20 mg/kg as a single dose, then 15–20 mg/kg every 6–8 h
3 months–12 years: 20 mg/Kg every 6 h
12–18 years: 0.5–1 g every 4–6 hours
Salbutamol, pressurised metered-dosed spray (1 puff/200 μg)1–2 puffs up to 4 times/day “…a maximum of 2 puffs at a time are recommended, which should not be repeated for at least 4 hours …”For acute mild to moderate exacerbations of asthma “give 1 puff every 15–30 seconds up to a maximum of 10 puffs; repeat dose after 20–30 minutes if necessary”
  • *Information for paracetamol is taken from the SPC of Tachipirina produced by Angelini, and for salbutamol from the SPC of Ventolin produced by Glaxo Wellcome.