| Amoxicillin QD | Penicillin V BID | |
| Patients randomised to treatment | 177 | 176 |
| Patients discontinuing treatment | 11 (6.2%) | 7 (4.0%) |
| Reasons for discontinuation | ||
| Lost to follow-up/left school | 3 (1.7%) | 1 (0.6%) |
| Parental request* | 5 (2.8%) | 4 (2.3%) |
| Lack of compliance | 1 (0.6%) | 1 (0.6%) |
| Hospital admission with acute | 1 (0.6%) | 0 |
| rheumatic fever† | ||
| Adverse event | 0 | 1‡ (0.6%) |
| Unknown | 1 (0.6%) | 0 |
*One child in the amoxicillin group and three children in the penicillin V group were withdrawn from the study by parental request as they wished to transfer care to their primary care physician; †see text; ‡the adverse event (not necessarily related to treatment) was vomiting.