Table 4

Comparison of diagnostic characteristics of vital signs, MTS, and NICE intermediate (amber) or high risk (red) features for identifying children with serious or intermediate infection vs those with minor/no infection

Sensitivity (95% CI)Specificity (95% CI)Positive LR (95% CI)Negative LR95% CI)
Vital signs:
⩾1 of temperature ⩾39°C, O2 sats ⩽94%, tachycardia, tachypnoea80 (75 to 85)39 (34 to 44)1.3 (1.2 to 1.5)0.5 (0.4 to 0.7)
MTS:
Urgent/very urgent/emergency84 (79 to 88)38 (33 to 43)1.3 (1.2 to 1.5)0.4 (0.3 to 0.6)
Very urgent/emergency24 (20 to 29)93 (90 to 96)3.4 (2.2 to 5.2)0.8 (0.8 to 0.9)
NICE risk features:
⩾1 intermediate risk (amber) feature73 (68 to 77)48 (43 to 53)1.4 (1.2 to 1.6)0.6 (0.5 to 0.7)
⩾1 high risk (red) feature66 (61 to 72)49 (44 to 54)1.3 (1.2 to 1.5)0.7 (0.6 to 0.8)
⩾1 intermediate or high risk features85 (81 to 89)29 (25 to 34)1.2 (1.1 to 1.3)0.5 (0.4 to 0.7)
  • LR, likelihood ratio; O2 sats, oxygen saturations.