Table 1

 Composition and stability of liquid captopril formulations used to treat children with heart disease in the UK

StrengthsExpiry (days)Stability data*Excipients
Suspension diluent A contains xanthan gum 1%, methyl hydroxybenzoate and propylhydroxy benzoate. St George’s Hospital, London, provided two extemporaneous methodologies.
*Evidence of comprehensive in-house stability data on the final finished product.
“Specials” manufacturer
    Cardinal Health Martindale ProductsVarious90Fractionated oconut oil, Cab-o-sil
    The Specials LaboratoryVarious28NoXanthan gum 1%, ascorbic acid
    Nova Laboratories (flavoured)Various28NoFlavoured suspension Diluent A in a 1:1 ratio with water, ascorbic acid
    Nova Laboratories (unflavoured)Various8NoSuspension diluent A in a 1:1 ratio with water
NHS manufacturing unit (St Mary’s Pharmaceutical Unit)1, 5 and 12.5 mg/ml35NoXanthan gum 0.4%, methyl hydroxyl-benzoate, propyl-hydroxy benzoate
Imported (Bristol–Myers Squibb, Australia)5 mg/ml28YesCitric acid, sodium citrate, disodium edetate, sodium benzoate
Extemporaneous formulations
    Southampton General Hospital1 mg/ml14NoAscorbic acid, water
    Bradford Royal Infirmary, Royal Hospitals, Belfast, and St George’s, LondonVarious14NoSuspension diluent A
    St George’s, LondonVarious14NoOraPlus/OraSweet (1:1 ratio)
    Queen’s Medical Centre, Nottingham,and Gloucester Royal InfirmaryVarious14NoSuspension diluent A in a 1:1 ratio with water