Table 2 Most frequent symptoms of CMPA*
Organ involvementSymptoms
Gastrointestinal tractFrequent regurgitation
Constipation (with/without perianal rash)
Blood in stool
Iron deficiency anaemia
SkinAtopic dermatitis
Swelling of lips or eye lids (angio-oedema)
Urticaria unrelated to acute infections, drug intake or other causes
Respiratory tractRunny nose (otitis media)20 21
(unrelated to infection)Chronic cough
GeneralPersistent distress or colic (wailing/irritable for ⩾3 h per day) at least 3 days/week over a period of >3 weeks
  • *Infants with CMPA in general show one or more of the listed symptoms.