| Organ involvement | Symptoms |
| Gastrointestinal tract | Frequent regurgitation |
| Vomiting | |
| Diarrhoea | |
| Constipation (with/without perianal rash) | |
| Blood in stool | |
| Iron deficiency anaemia | |
| Skin | Atopic dermatitis |
| Swelling of lips or eye lids (angio-oedema) | |
| Urticaria unrelated to acute infections, drug intake or other causes | |
| Respiratory tract | Runny nose (otitis media)20 21 |
| (unrelated to infection) | Chronic cough |
| Wheezing | |
| General | Persistent distress or colic (wailing/irritable for ⩾3 h per day) at least 3 days/week over a period of >3 weeks |
*Infants with CMPA in general show one or more of the listed symptoms.