Table 1 Alarm symptoms and findings (can be found alone or in combination with items listed in table 2), indicating severe CMPA as the possible cause
Organ involvementSymptoms and findings
Gastrointestinal tractFailure to thrive due to chronic diarrhoea and/or refusal to feed and/or vomiting
Iron deficiency anaemia due to occult or macroscopic blood loss
Hypoalbuminaemia
Endoscopic/histologically confirmed enteropathy or severe colitis
SkinExudative or severe atopic dermatitis with hypoalbuminaemia or failure to thrive or iron deficiency anaemia
Respiratory tractAcute laryngoedema or bronchial
(unrelated to infection)obstruction with difficulty breathing
GeneralAnaphylaxis