Table 2

 Bisphosphonate studies in other connective tissue diseases

StudyIntervention groupAge (mean±SD) and sexBisphosphonate: dose and routeFollow upDensitometryOutcome
*An abstract only was available from Embase, a full copy of the paper was not available from UK sources.
†Conference abstract.
OI, osteogenesis imperfecta.
Case series
*Bardare et al (2000)276 patients with corticosteroid induced osteoporosis: SLE (5), dermatomyositis (1)15.7 years (range 10.9–18.1)
>5 F, 1 M
Alendronate oral 10 mg/day2 yearsDXA. After 1 year: mean increase in lumbar spine aBMD 19.1% (range 4.9 to 38%). After 2 years: mean improvement 6%Not evaluated/reported
Falcini et al (1996)284 patients with rheumatic disease or drug induced osteoporosis: post-streptococcal (1), polyarteritis (1), lupus-like syndrome (1), dermatomyositis (1)10 years 6 months, (range 6–13 years)
>4 F
Alendronate infusion 3.25 mg/day for 3 consecutive days, second course 3 months later1 yearDXA. Mean baseline lumbar spine aBMD = 0.654 g/cm2 (range 0.595 to 0.722 g/cm2). After 12 months, mean = 0.764 g/cm2 (range 0.655 to 0.860 g/cm2)Not evaluated/reported
†Bayer et al (2002)339 patients: corticosteroid-induced osteoporosis (3) OI (6)12.3±1.7 years
>7 M, 2 F
Alendronate oral 5 or 10 mg/day12.9±1.5 monthsBaseline Z-scores were −4.2±2.2 for lumbar spine and −2.3±1.1 for total body. After 12 month’s treatment: spine BMD increased to −3.1±1.6 (p<0.02) and total body aBMD to −2.0±1.5 (p<0.2)Not evaluated/reported
Chlebna-Sokol et al (2003)315 patients treated with bisphosphonates: OI (2), idiopathic osteoporosis (1), secondary osteoporosis (2)Range 10.2–18.2 years
>4 M, 2 F
Bisphosphonates6 months to 12 monthsDXA. Total body aBMD Z-score range, baseline: −3.76 to −1.43, 6 months: −3.12 to −0.9, 12 months: −2.90 to −0.90
>Lumbar spine aBMD Z-score range, baseline: −5.09 to −3.00, 6 months: −2.85 to −2.00, 12 months −2.50 to −1.18
Decrease in C-terminal cross-linked telopeptide of type I collagen, osteocalcin levels fell in two children but increased in three children, dypyridinoline:creatinine and pyridinoline:creatinine ratios fell in most children
Case report
Oliveri et al (1996)34Dermatomyositis (1)8 years
>F
Pamidronate oral, 4 mg/day21 monthsDXA. At baseline total body aBMD = 0.790 g/cm2, Z-score = −2.1. aBMD lumbar spine 0.533 g/cm2, Z-score −3.6. After 21 months, aBMD = 1.047 g/cm2, Z-score = 1.0. Lumbar spine aBMD = 1.02 g/cm2, Z-score = 0.43Serum levels of ALP remained within normal range