Table 2

 Mean (SD) plasma sodium and osmolality at baseline (T0) and after 4 hours of intravenous rehydration (T4) in the initially hyponatraemic (plasma sodium <135 mmol/l) versus normonatraemic (plasma sodium 135–145 mmol/l) children who received either 0.45% saline + 2.5% dextrose (N/2) or 0.9% saline + 2.5% dextrose (NS)

N/2 (n = 51)NS (n = 51)
Hyponatraemic (n = 16)Normonatraemic (n = 35)p valueHyponatraemic (n = 21)Normonatraemic (n = 30)p value
*p<0.001, T4 versus T0.
†p = 0.003, hyponatraemic children NS versus N/2.
‡p<0.001, normonatraemic children NS versus N/2.
T0 sodium (mmol/l)132 (1.5)137 (1.7)132 (2.4)137 (2.2)
T4 sodium (mmol/l)133 (1.8)135 (1.8)*<0.001134 (2.1)*138 (2.9)<0.001
Change in sodium (mmol/l)+0.4 (1.7)−2.3 (2.2)<0.001+2.4 (2.0)†+0.8 (2.4)‡0.02
Sodium decreased ⩾ 2 mmol/l from 0–4 hours13% (2/16)51% (18/35)<0.010% (0/21)13% (4/30)0.13
T0 osmolality (mOsm/kg)277 (6.3)283 (7.2)0.005277 (6.9)284 (6.9)0.001
T4 osmolality (mOsm/kg)276 (4.4)278*(5.0)0.21279 (4.3)283 (6.7)0.01