Effect of probiotic treatment on the clinical severity of AD
| Week 2 | Week 4 | Week 8 | Week 16 | |
|---|---|---|---|---|
| Values are presented as medians (25th percentile to 75th percentile). Change is the change in score from baseline. | ||||
| * **Significant change over time (p = 0.03*, p<0.001**, Friedman’s analysis of variance). | ||||
| Probiotic | ||||
| Change in the SCORAD index* | −8.25 (−13.8 to 0.5) | −6.2 (−14.2 to −3.6) | −18.2 (−22.1 to −2.4) | −17 (−24.6 to −9.8) |
| Change in extent** | −4.5 (−12.25 to 3.25) | −8.5 (−12.25 to 4) | −14 (−16.8 to −5.25) | −16 (−22 to −6.75) |
| Change in intensity | −1 (−2 to 0) | −1 (−2 to −0.25) | −2 (−3.8 to −1) | −3 (−4 to 0) |
| Change in subjective score | −2.4 (−5.9 to 1) | −1 (−6.8 to 2.9) | −4.2 (−8 to −0.9) | −4 (−6.75 to −2) |
| Placebo | ||||
| Change in the SCORAD index | −4.2 (−12.6 to 2.25) | −3.9 (−17.4 to −0.3) | −10.2 (−23 to 3.6) | −12 (−20 to 5) |
| Change in extent | −5.25 (−16.2 to −0.5) | −6.75 (−15.4 to 1.6) | −9 (−22.6 to 5.8) | −11 (−23.1 to −3.2) |
| Change in intensity | −1 (−2 to 0) | −1 (−2 to 0) | −1 (−3.3 to 2) | −1 (−3 to 2) |
| Change in subjective score | −1.25 (−4.75 to 2.3) | 0 (−6 to 2.4) | −1.4 (−6.6 to 1.6) | −2.25 (−6 to 0.6) |