Double blind, placebo controlled in adults, 3 weeks | DSM-III-R criteria by the age of 7 years | Chronic medical conditions | ADHD-RS; HDRS; HARS; BDI | Spencer et al14 |
IQ <75 |
Organic brain disorders |
Active psychiatric conditions |
History of drug or alcohol abuse |
Pregnancy or nursing |
Open label trial in children; 10 weeks | DSM-IV | No information given | ADHD Rating Scale IV - parent version; CGI; CPRS-R:S | Kratochvil et al15 |
Open label, dose ranging study in children; 11 weeks | DSM-IV | Clinically significant medical conditions | ADHD Rating Scale IV; CGI; CPRS-R:S; ODD-RS | Spencer et al16 |
Mental retardation; unstable psychiatric condition |
History of drug or alcohol abuse |
Current use of psychotropic medication |
Randomised, placebo controlled, dose response study in children; 8 weeks | DSM-IV; ADHD Rating Scale IV – parent version | Serious medical illness | ADHD-RS; CPRS-R; CDRS-R; CGI-S; CHQ | Michelson et al8 |
Comorbid psychosis |
IQ <80. |
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Randomised, open label trial in children; 10 weeks comparator with methylphenidate | DSM-IV diagnostic criteria | History of bipolar or psychotic disorders | ADHD RS (investigator and parent rated); CPRS-R; CGI | Kratochvil et al10 |
Motor tics or family history of Tourette syndrome |
Substance abuse. |
Two randomised, placebo controlled, proof of concept studies in children; 12 weeks | DSM-IV diagnostic criteria; ADHD Rating Scale IV - Parent: Investigator Administered and Scored | Poor metabolisers of CYP2D6 | ADHD-RS; CGI; CPRS | Spencer et al22 |
Weight <25 kg |
History of psychosis or seizure disorder |
History of alcohol or drug abuse |
Randomised, placebo controlled study in adults; 10 weeks | DSM-IV defined ADHD as assessed by clinical interview and confirmed by CAAR-D | Major depression or anxiety disorder | CAARS; CGI-S; WRAADDS | Michelson et al17 |
Psychotic disorders |
History of alcohol or drug abuse |
Once daily, randomised, placebo controlled study in children; 6 weeks | DSM-IV criteria; Investigator administered and scored parent version of ADHD Rating Scale IV | Serious medical illness | ADHD-RS; CGI; CPRS; CTRS | Michelson et al13 |
History of psychosis |
History of alcohol or drug abuse |
Once-daily atomoxetine in childhood ADHD: continuous symptom relief; weeks | DSM-IV criteria; Investigator administered and scored parent version of ADHD Rating Scale IV | Serious medical illness | ADHD-RS; DPREMB-R; CGI-PE | Kelsey et al25 |
History of psychosis or bipolar disorder |
History of alcohol or drug abuse. |
Placebo controlled study of once-daily atomoxetine in the school setting | DSM-IV criteria; Investigator administered and scored parent version of ADHD Rating Scale IV | Serious medical illness | ADHD-RS (teacher version); APRS; BADDS | Weiss et al37 |
Use of other psychotropic medication |
Evidence of significant intellectual deficit |