Table 1

Case-control study (GPRD) of hay fever and vaccinations

Vaccine	Month(s) of life	Counts (%) cases + controls	Unadjusted*			Adjusted†			Adjusted‡
Vaccine	Month(s) of life	Counts (%) cases + controls	OR	95% CI	p value	OR	95% CI	p value	OR	95% CI	p value
OR, odds ratio; 95% CI, 95% confidence interval.
*Unadjusted matched pairs analysis (4196 pairs for DTP and MMR, 4189 pairs for BCG).
†Adjusted for consultation frequency and restricted to pairs with non-ghost controls (3859 pairs for DTP and MMR, 3852 pairs for BCG).
‡Further adjusted for numbers of older and younger sibs and multiple births (3859 pairs for DTP and MMR, 3453 pairs for BCG).
Tests for trend (non-ghost control pairs and adjusted for consultation frequency).
DTP: 0.92 (0.87, 0.97), p = 0.003; MMR: 0.96 (0.92, 0.99), p = 0.02.
		8392 (100)
DTP	DTP3 1st–4th	1087(13.0)	0.91	0.78 to 1.06	0.22	0.94	0.78 to 1.12	0.48	0.90	0.75 to 1.08	0.26
	DTP3 5th	2786 (33.2)	1			1			1
	DTP3 6th	1178 (14.0)	1.01	0.87 to 1.17	0.88	1.06	0.89 to 1.27	0.50	1.10	0.92 to 1.31	0.31
	DTP3 7th–9th	1163 (13.9)	0.78	0.66 to 0.92	0.004	0.73	0.59 to 0.91	0.004	0.80	0.64 to 0.99	0.04
	DTP3 10th–12th	1165 (13.9)	0.75	0.60 to 0.94	0.01	0.85	0.64 to 1.13	0.27	0.93	0.70 to 1.24	0.63
	DTP3 13th +	482 (5.7)	0.53	0.40 to 0.69	<0.0001	0.58	0.41 to 0.81	0.002	0.64	0.45 to 0.90	0.01
	Other DTP	183 (2.2)	0.81	0.57 to 1.15	0.23	0.83	0.54 to 1.27	0.39	0.86	0.55 to 1.33	0.49
	No DTP	346 (4.1)	0.90	0.70 to 1.16	0.42	0.91	0.66 to 1.26	0.56	1.01	0.73 to 1.33	0.95
MMR	1st–13th	1688 (20.1)	1.00	0.86 to 1.16	0.97	0.98	0.82 to 1.18	0.84	0.97	0.81 to 1.16	0.74
	14th	2311 (27.5)	1			1			1
	15th	1638 (19.5)	0.84	0.73 to 0.97	0.02	0.88	0.74 to 1.04	0.13	0.89	0.75 to 1.06	0.19
	16th	1183 (14.1)	0.92	0.77 to 1.09	0.34	0.93	0.76 to 1.15	0.50	0.93	0.75 to 1.14	0.48
	17th	510 (6.1)	0.96	0.76 to 1.20	0.69	0.94	0.72 to 1.23	0.64	0.96	0.73 to 1.25	0.75
	18th–24th	618 (7.4)	0.78	0.64 to 0.95	0.01	0.86	0.68 to 1.10	0.23	0.89	0.70 to 1.14	0.37
	25th+	234 (2.8)	0.69	0.52 to 0.92	0.01	0.77	0.54 to 1.08	0.13	0.83	0.58 to 1.18	0.29
	No MMR	210 (2.5)	0.59	0.42 to 0.82	0.002	0.77	0.50 to 1.17	0.22	0.81	0.53 to 1.24	0.33
BCG	BCG <2 y	198 (2.4)	1.39	0.99 to 1.95	0.06	1.25	0.85 to 1.85	0.26	1.36	0.91 to 2.05	0.14
	No BCG/>2 y	8180 (97.6)	1			1			1