Australia Two centres16 | Parallel | 250 mg daily | 60 adults | 3 | Mean relative difference +3.6% | ↓ intravenous antibiotics ↑ quality of life | ↓ CRP | Nil |
UK Single centre17 | Crossover | 250 or 500 mg daily | 41 children >8 y | 6 | Median relative difference +5.4% | ↓ oral antibiotics | No difference sputum IL-8, neutrophil elastase | Nil |
USA Multicentre19 | Parallel | 250 or 500 mg 3/week | 185 children >6 y and adults | 6 | Mean relative difference +6.2% | ↓ nonquinolone antibiotics ↓ exacerbation ↑ weight | Modest ↓ sputum elastase, no difference IL-8 | Nausea, diarrhoea, wheezing |