Duration of treatment | Anticipated height deficit | Anticipated change in height z-score | Required number of individuals per group (n) |
---|---|---|---|

*Calculated using the formula: n = 16/f^{2}; where n, number in each group, f, expected change expressed as a fraction of the standard deviation. The standard deviation for height was taken as 6.0 cm and the cohort standard deviation in z-scores was estimated as 1.0 to 1.2. | |||

1 year | 1.0 cm | −0.17 | 554–797* |

2 years | 2.0 cm | −0.33 | 147–212* |

3 years or more | 3.0 cm | −0.5 | 64–92* |