Table 3

 Follow up and outcome of children with hemihyperplasia

CitationPatient groupStudy typeOutcomeKey resultsComments
Hoyme et al (1998)4168 childrenProspective multicentre study of incidence of neoplasia and follow up over 10 year periodTumour development on follow up abdominal ultrasoundTumour incidence 5.9% (95% CI 2.3%–8.2%) compared to 0.17% in general population; follow up protocol varied among respondents; mostly abdominal palpation 6–12 monthly and USS abdomen 6 monthlyProspective multicentre study, over 10 year period. Relatively large number of patients (with a rare condition). No control group Varied follow up protocols, varied duration of follow ups; tumour surveillance protocol suggested; abdominal USS 3 monthly till 6 years of age and 6 monthly afterwards until puberty
Choyke et al (1999)574 childrenCase series comparing late stage Wilm’s tumour in patients with BWS/HH who are screened with ultrasound scans (4 monthly) against those who are not screenedFollow up sonograms; tumour developmentNone of the screened (n = 14) had late stage (stage III or IV) Wilm’s tumour whereas 25 out of the 59 unscreened had late stage disease; benefit from sonograms at intervals of 4 months or lessCase series Both BWS and HH included in the study and hence difficult to correlate risk of tumour development and screening to isolated HH alone Small sample size, especially the screened group